diff --git a/routes/meshtastic.py b/routes/meshtastic.py
index f8629d6..0f78b69 100644
--- a/routes/meshtastic.py
+++ b/routes/meshtastic.py
@@ -57,6 +57,38 @@ def _message_callback(msg: MeshtasticMessage) -> None:
             pass
 
 
+@meshtastic_bp.route('/ports')
+def list_ports():
+    """
+    List available serial ports that may have Meshtastic devices.
+
+    Returns:
+        JSON with list of available serial ports.
+    """
+    if not is_meshtastic_available():
+        return jsonify({
+            'status': 'error',
+            'ports': [],
+            'message': 'Meshtastic SDK not installed'
+        })
+
+    try:
+        from meshtastic.util import findPorts
+        ports = findPorts()
+        return jsonify({
+            'status': 'ok',
+            'ports': ports,
+            'count': len(ports)
+        })
+    except Exception as e:
+        logger.error(f"Error listing ports: {e}")
+        return jsonify({
+            'status': 'error',
+            'ports': [],
+            'message': str(e)
+        })
+
+
 @meshtastic_bp.route('/status')
 def get_status():
     """
diff --git a/static/js/modes/meshtastic.js b/static/js/modes/meshtastic.js
index 8efcdcc..133eb5d 100644
--- a/static/js/modes/meshtastic.js
+++ b/static/js/modes/meshtastic.js
@@ -24,9 +24,43 @@ const Meshtastic = (function() {
      */
     function init() {
         initMap();
+        loadPorts();
         checkStatus();
     }
 
+    /**
+     * Load available serial ports and populate dropdown
+     */
+    async function loadPorts() {
+        try {
+            const response = await fetch('/meshtastic/ports');
+            const data = await response.json();
+
+            const select = document.getElementById('meshStripDevice');
+            if (!select) return;
+
+            // Clear existing options except auto-detect
+            select.innerHTML = '<option value="">Auto-detect</option>';
+
+            if (data.status === 'ok' && data.ports && data.ports.length > 0) {
+                data.ports.forEach(port => {
+                    const option = document.createElement('option');
+                    option.value = port;
+                    option.textContent = port;
+                    select.appendChild(option);
+                });
+
+                // If multiple ports, select the first one by default to avoid auto-detect failure
+                if (data.ports.length > 1) {
+                    select.value = data.ports[0];
+                    showStatusMessage(`Multiple ports detected. Selected ${data.ports[0]}`, 'warning');
+                }
+            }
+        } catch (err) {
+            console.error('Failed to load ports:', err);
+        }
+    }
+
     /**
      * Initialize the Leaflet map
      */
@@ -91,7 +125,15 @@ const Meshtastic = (function() {
         // Try strip device select first, then sidebar
         const stripDeviceSelect = document.getElementById('meshStripDevice');
         const sidebarDeviceSelect = document.getElementById('meshDeviceSelect');
-        const device = stripDeviceSelect?.value || sidebarDeviceSelect?.value || null;
+        let device = stripDeviceSelect?.value || sidebarDeviceSelect?.value || null;
+
+        // Check if auto-detect is selected but multiple ports exist
+        if (!device && stripDeviceSelect && stripDeviceSelect.options.length > 2) {
+            // Multiple ports available - prompt user to select one
+            showStatusMessage('Multiple ports detected. Please select a specific device from the dropdown.', 'warning');
+            updateStatusIndicator('disconnected', 'Select a device');
+            return;
+        }
 
         updateStatusIndicator('connecting', 'Connecting...');
 
@@ -1164,6 +1206,7 @@ const Meshtastic = (function() {
         init,
         start,
         stop,
+        loadPorts,
         refreshChannels,
         openChannelModal,
         closeChannelModal,